Virtualization offers quite a few advantages for customers running large data centers but care needs to be taken when using memory replication technologies like DataGrids. The particular problem here is that each virtual machine looks like a real server as far as middleware running within that virtual machine. Each virtual machine has its own IP address for example. If you are keeping a primary copy and a backup copy of critical data in a DataGrid then it's essential that those copies have a few common failure modes as possible.
The first most obvious one is simply make sure they are in different processes. This is quickly followed by make sure they are in separate servers. This is where virtualization gets you in trouble. A DataGrid might mistakenly place the primary and backup copies in two virtual machines running on the same physical server. This clearly is dangerous. A single hardware failure and you'll lose both copies.
WebSphere eXtreme Scales zone support can avoid this problem. Assign each physical server a zone id. A zone id is simply a string. Make sure each JVM in virtual machines running on that physical server uses the same zone identifier. WebSphere eXtreme Scale will then automatically only place copies on a different physical zone from the one containing the primary copy. This neatly avoids the problem as WebSphere eXtreme Scale handles it automatically once you tell it the zones.
This also highlights some of the dangers with virtual machine migration. This would cause a problem here as moving the virtual machine wouldn't change the zone identifier in use automatically. Virtualization is a new technology and many of the supposed features that make it cool take a very simplistic view of the requirements of software running on those virtual machines. They assume they can add/remove CPUs, memory, move boxes without impacting software running on those virtual machines. This is a naive view of the world unfortunately and many customers are believing the hype from the hypervisor vendors. Be suspicious of these claims, if it looks too good to be true then it usually is.